Bio-Nanosystems Laboratory

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Biomimetic formation and organization of magnetite nanoparticles, ERA-Chemistry/ OTKA NN117640 project;
Project leaders:
 Dr. Mihály Pósfai, Dr. Ferenc Vonderviszt

One-dimensional magnetic nanostructures have magnetic properties superior to non-organized materials due to a strong uniaxial shape anisotropy. Magnetosome chains in magnetotactic bacteria represent a biological paradigm of such a magnet, where magnetite crystals of controlled dimensions are synthesized in organelles called magnetosomes and are arranged into linear chains. The biological materials thus display a hierarchical architecture that is hardly matched by synthetic materials. In this project, we aim at applying the design principles used by the microorganisms to grow one-dimensional magnetic nanostructures along biological templates. With the aim of creating one-dimensional magnetic nanostructures, we genetically engineer flagellar filaments produced by Salmonella bacteria to display iron- or magnetite-binding sites, and use the mutant filaments as templates for both nucleation and attachment of the magnetic iron oxide magnetite.



GINOP-2.3.2-15 – Strategic R&D workshops of excellence:Bio-nanotechnological research for efficient diagnosis of diseases, development of novel drug carriers and bio-inspired intelligent nanomaterials. WP3: Self-assembling bio-inspired nanomaterials
Project leader: Dr. András Guttman
WP3 coordinator: 
Dr. Ferenc Vonderviszt

This project aims at (1) development of cutting-edge micro- and nanodiagnostic protocols for early diagnosis of various cancer diseases, (2) constructing functional nanoparticles applicable in controlled drug delivery, and (3) creating self-assembling intelligent nanomaterials. In WP3, the problem is addressed how to fabricate self-assembling tubular nanostructures displaying catalytic and target recognition functionalities.



M-ERA.NET-WaterSafe: Sustainable autonomous system for nitrites/nitrates and heavy metals monitoring of natural water resources”/OTKA NN117849 project, 2016-2018. Task 2.2-4: Development of flagellin-based sensing layers
Project co-leader: 
Dr. Ferenc Vonderviszt

The project sets to develop a new energy autonomous system based on (photo) electrochemical sensors for detection of different ionic species in natural water sources and ultra-thin solar cells (UTSC). In WP2, bacterial flagellar filaments will engineered and used to form sensitive biolayers for heavy metal detection. Flagellin, the subunit protein of bacterial flagellar filaments, is a protein polymerizable to form long filaments. The central portion of the amino acid sequence of flagellin, which forms the outer part of the filament, is highly variable, and can be modified by genetic engineering or chemical treatment without affecting polymerization ability. Our aim is to engineer the central portion of flagellin for selective capture of metal ions without disturbing its polymerization ability, and to use these modified flagellins to build filamentous nanostructures. The elements could be anchored to the transducer surface possessing surface binding functionality. These filamentous receptor structures can serve as the basic recognition units in bio- and chemical sensors monitoring the toxic metal content of natural waters.



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